Screening Libraries

During our synthetic and screening endeavors, we have developed a range of approaches to both chemical diversity and highly specialized (focused) compound selections. ChemDiv’s libraries have been extensively validated both in our in-house biological assays and in the laboratories of over 200 external partners including Pharma, Biotech, Academia and Screening Centers in the U.S., Europe, and Japan.

We offer a shelf-available set of over 1.6 M individual solid compounds,

Low molecular weight organic compounds collection is updated quarterly and reflects to novel insight into molecular, cell biology, availability of novel ligands or overall trends in disease areas and observe modern definitions of lead-like properties. We provide specialized chemical libraries focused on chemical diversity-, soluble diversity-, blood-brain permeability, rigid topology (spiro-heterocycles and macrolide analogs), Fsp3 character, medium- and large-size rings (macrocycles), and other criteria.

A custom selection of compounds that suits your specific needs could be dispatched in any custom format to you within 1-3 weeks.

Focused and targeted screening compounds libraries

To meet a wide range of research needs of small molecules screening projects, ChemDiv has a carefully designed set of diversified Targeted and Focused libraries. Focused and targeted compounds libraries cover over 20 therapeutic areas,  target families including GPCR, Ion Channels, Kinases, Proteases, Phosphotases, Nuclear receptors, different mechanism of actions, PPI modulators, various receptors ligands, epigenetic mechanisms and specific structural motives grouped in screening sets like mimetics compounds,  macrocylces, spiro compounds, indioles, cyclic compounds, fragments, covalent inhibitors, natural and natural-based small molecules.

There are assembled screening sets for agrochemical, including antifungal compounds, antiparasitic libraries. Small molecules conform to the Generally Recognized as Safe (GRAS) concepts in cosmetics and food industries.

SaRs-CoV (2) Targeted screening library Selection

Covalent  inhibitors screening libraries (design and warheads)

Our computational, structural biology, synthetic and medicinal screening team follows current trends in modern structure-based drug discovery to adds novel diverse and targeted compounds. The latter selections are aimed at tackling multiple targets, protein domains, pathways, cellular processes, etc. Representative examples of these biased Screening libraries include modulators of numerous protein-protein interactions, stem cell differentiation, apoptosis, proteasome cascade including diverse ligases, autophagy, epigenetics machinery, cell cycle including quiescent cancer cells, motor proteins, mitochondrial homeostasis and cell energetic, viral targets, bacterial genome, protein folding machinery including scaffolding proteins and chaperones and many others. Our general approach to these sets includes analysis of the available chemical and biological information, identification of key pathway nodules/targets, computational and ‘wet biology’ assessment of target draggability and potential binding domains. The resulting information is analyzed by our synthetic team to design scaffolds for novel chemical libraries production that are likely to interact with the designated targets yielding focused screening compound libraries and Libraries for Hit Identification.

Biological activity Annotated screening libraries

Diversity compounds library is the best solution for your chemical screening projects. ChemDiv’s diversity screening sets represent validated drug-like chemistry space of over 13B chemical compounds and 1.6M stock compounds collection.

Our compounds screening libraries have a perfect diversity scoring by Tanimoto similarity threshold, by bias against undesirable structural patterns. Structural enrichment is done with the focus on novel chemistry by Markush fragments. The scaffolds are prioritized by structural complexity, by 3D shape diversity and Fsp3 distribution range. All chemical compounds passed REOS and PAINS filters, have high MCE-18 score, optimized solubility, and «target diversity» approach in biological activity.

A list of diversity screening compounds libraries includes 9 compounds libraries prepared using different design approaches.

100,000 maximum diversity preplated screening compounds library represents 1.6m stock available screening compounds collection and 13B virtual space of drug-like and lead-like chemical compounds. The collection has perfect diversity scoring by Tanimoto similarity, includes concentric diversity subsets 20k-30k-50k-100k. Structural enrichment is done with the focus on novel chemistry by Markush fragments. All screening compounds passed REOS and PAINS, have high MCE-18 score optimized solubility and «target diversity» approach in biological activity. Chemical compounds from over 70 targeted and focused libraries are included. Customers can cherry-pick small molecules by plates.

Concentric screening diverse subsets with 100k 54k 30k and 20k compounds

300k Representative Screening Compounds Library selected with Bemis-Murcko Clustering Algorithm includes 200 000 unique BMS and number of 3-50 small molecules per each BMS.

3D-Pharmacophore Based Screening Diversity Library is designed taking into consideration that proteins contain binding sites different in their spatial geometry and potential hot-spots / binding points for small molecule compounds. Following the “Picklock” Concept, a library that contains a minimal number of compounds with high diversity in terms of potential pharmacophore points could be applied for any protein to obtain primary hits during HTS campaigns.
Each molecule has 3D-conformation generated in Corina Software. Three the most different 3-centered pharmacophore hypothesis have been automatically constructed per a conformation mainly focusing on HBA, HBD and HYD/LIPO/ARO points. All the generated pharmacophore hypothesis has been then clustered to obtain a pool of the most divers 3D-models. 13B small molecules have been subsequently screened in silico using this pool.  The most divers virtual compounds hits have been then selected from each pharmacophore pool. These screening compounds properly cover the operating chemical space.

Soluble Diversity Screening Library is aimed to improve biophysical properties including solubility and drug-like properties of the screening set while maintain its chemical diversity. We anticipate that this set will address the undesired „supra-molecular‟ phenomena in the in vitro/ex vivo assays associated with aggregation, precipitation or formation of colloidal systems.

‘Soluble diversity” set is designed consistent with key points, namely:

— Predicted high solubility of compounds (logSW > -2.0).
— High diversity of substances. The current set is built around 500 diverse scaffolds to yield a library of 10K compounds.
— Novelty. A special effort has been made to select compounds and scaffolds with good IP potential.
— High chemical quality. The special rules of ChemDiv‟s medchem filters ensure the high quality of selected drug-like molecules. All unwanted chemotypes or compounds bearing reactive groups were removed (e.g. Michael acceptors, redox agents, polyaromatics, epoxides, quinones, etc.).
— Good physico-chemical properties of compounds selected. A variety of criteria was considered for this library selection; among those are:

  • MW ≤ 450
  • ClogP < 5.0
  • ClogD < 5.0
  • RB < 10
  • HBA < 10
  • HBD ≤ 5
  • PSA < 100

3D diversity is pivotal because the molecular shape is a crucial factor in molecular recognition by a biomolecule. 3D-Diversity Natural-Product-Like Screening Library contains 1479 clusters based on the pharmacophore 3D-similarity metric and 738 unique heterocycles. The key concepts that the chemical library design is based on are 3D shape, pharmacophore diversity, drug-likeness, and chemical beauty. Natural products (NP) have been widely used for the treatment of diseases and illnesses since antient times. Analysis of natural products  over the past 30 years revealed that approximately 40% of the developed therapeutics drugs approved by FDA were NPs, NP derivatives, or synthetic mimetics related to NPs. With their highly and sophisticated biological and chemical diversity, NPs and their derivatives have been used to explore biologically relevant space. The significant impact of NPs on the discovery of therapeutic agents is based on their embedded biosynthetic molecular recognition.

The concept of Targeted Diversity chemical space is intended for the design of high-quality screening libraries of drug-like compounds that have been focused against various biological targets. Targeted diversity signifies the superposition of highly diverse chemical space on the assortment of divergent families or sub-families of targets and unique biomolecules. Targeted Diversity make possible the design of high-quality discovery chemical libraries of drug-like molecules, selectable focused against different biological targets. This concept also uses the superposition of a highly diverse chemical space on a representative assortment of divergent families & sub-families of targets, signaling, and transport molecules. The Targeted Diversity concept is a broadly applicable platform approach, for it can be used to design and/or select high quality screening libraries of drug-like compounds focused in individual therapeutics areas, target families, or control pathways.

A major benefit of Smart Library approach is that it represents a thoughtful and multi-purpose diversity set, incorporated it into one single compound library for different screening goals. Those goals may include: “Difficult” targets (no target/ligand structure(-s) known, study and interrogation of cellular processes (e.g. apoptosis, cell cycle, etc.); Signaling pathways (e.g. WNT, Hh, RTK, Ras, etc.) and “eclectic” biological targets, including cellular processes (e.g. apoptosis and cell cycle); Protein-protein interactions (the most «hot spots», e.g. XIAP, pGPCRs, beta-catenin, etc.); An entire selected therapeutic area that incorporates multiple biological targets;

The paradigm of “drug likeness” dramatically altered the behavior of the medicinal chemistry community for a long time. In recent years, scientists have empirically found a significant increase in key properties of drugs that have moved structures closer to the periphery or the outside of the rule-of-five “cage”. Herein, we show that for the past decade, the number of small molecules claimed in patent records by major pharmaceutical companies has dramatically decreased, which may lead to a “chemical singularity”. New screening compounds containing fragments with increased 3D complexity are generally larger, slightly more lipophilic, and more polar. A core difference between this study and recently published papers is that we consider the nature and quality of sp3-rich frameworks rather than sp3 count. We introduce the original descriptor MCE-18, which stands for Medicinal Chemistry Evolution, 2018. This measure can effectively score molecules by novelty in terms of their cumulative sp3 complexity.

The drug discovery process is long and expensive. Our aim is to shorten this process by producing high-quality, hit-like, lead-like, and drug-like screening compounds that generate valuable data from discovery screening programs.

If you have an existing therapeutic target but no chemical starting point, we can be your partner to find such a lead and accelerate drug discovery.

Chemical arrays as small as 20 and as large as 500 members can be custom-made or picked up from the existing stock reflective of the structure-based assessment of a target or pathway. Notably, all screening compounds are chosen to exhibit a range of drug-like and lead-like properties. Generally, our team requests ca. 2 weeks to generate and propose set of libraries (10-25+) addressing your biological interests. Select it immediately from existing stock of 1.6 M screening compounds.

All chemical libraries for lead discovery are regularly updated at the rate of 100K new screening compounds per year with our novel, IP-defined compounds resulting from the internal development. We are pleased to consider and adopt your custom protocols in order to make focused inhibitors set(s) that suit your specific needs. Our highly diverse molecules are produced using ‘traditional’ synthetic approaches with yields of up to 100-150 mg per compound and average purity greater than 92% as determined by both NMR and LCMS analyses. Complimentary to our proprietary chemotypes, we also offer a selection of custom building blocks.

In addition to producing libraries, we could be your partner of choice for screening. For the list of our in vitro, ex vivo and in vivo assay capabilities, please visit this Biology Services.

ChemDiv ensures resupply, resynthesis, immediate active chemical analogs selection, medchem FTE support for H2L.

What do you need to know about CBD?

If you have recently heard about CBD on some media platform, you might be curious to know more about it because everywhere you will hear about CBD, you will come to know about its benefits. Everyone would be boosting about how beneficial it can be for you and your health and how there are so many products that you can use made from CBD.  Chances are that you could have heard the mention of CBD name on some ad on media where it is used as a booster to be added to your morning coffee or your post-workout smoothie. It will give you amazing results and you would be fascinated by the use of it etc.

But the question that might come to your mind would be, what is this CBD? Why is it so popular and how it can be used? There are a lot of things that we listen about on some media platforms and later we like to search about them. so this post is about CBD and here you are going to know all that needs knowing about it.

What is CBD?

CBD is the most prevalent form of cannabis that is known by the name marijuana as well. it is an active ingredient that is used in a good number of products that are used for health, medicinal, and several other purposes. It is derived directly from the plant hemp or it is manufactured in the laboratory.

Does it make you go high?

Unlike the other substances that are derived from the plants of marijuana and hemp, CBD is not something that makes you go high. This has been declared by the world health organization as well that the research to date has revealed that there is no such thing as getting high that comes from CBD and negatively affects the human body.

Is CBD legal to use?

The use of CBD is either legal or not, is not something very clear till now because some states forbid the sale and purchase of CBD openly while there are other areas as well that allow it because there are no known side effects of it. the private label CBD products are being sold around easily and there is no trouble in the use of these products. So the best thing to do is to first learn about the legal status of CBD in your area and then make use of it.

The Vampire Facelift Procedure

The Vampire Facelift is an effective procedure to revive your skin. It uses platelet-rich plasma, a component of your own blood. This substance triggers the body’s wound-healing process, which produces new collagen. As a result, you will experience beautiful, youthful skin after the procedure.

The procedure involves puncturing the skin using platelets of your own blood. Your blood is drawn from an arm and spun in a centrifuge. This platelet-rich plasma stimulates the production of collagen and elastin.

This procedure helps tighten the skin and improves color and texture. The results can last for years. If you’re considering the Vampire Facelift, contact your doctor today to schedule a consultation.

The Vampire Facelift is a surgical procedure that can improve the appearance of aging skin. PRP is derived from the body’s own growth factors and is an ideal solution for rejuvenating the face. The PRP stimulates the body’s natural process to produce new collagen.

The Vampire Facelift is suitable for most people, but only after an initial consultation to ensure the procedure is right for you. You should also know that you cannot undergo the procedure if you suffer from severe wrinkles or acne.

A Vampire Facelift is a nonsurgical procedure that uses a platelet-rich plasma (PRP) injection. The PRP will trigger the healing process by stimulating the production of new skin cells and tissue. The procedure can be painful, but it won’t leave you scarring. The procedure can last anywhere from a few months to a year.

If you plan to undergo this treatment, make sure you arrive with clean skin and avoid unprotected exposure to the sun. You should also schedule a ride home if possible, as you’ll need a ride.

The procedure uses platelet-rich plasma to stimulate the healing process and restore your skin’s youthful appearance. Because the treatment is nonsurgical, the vampire facial is not a permanent solution for aging skin.

However, it is a fantastic option for patients who want to improve their appearance and have confidence. It is a long-term investment in their health. The treatment can be an affordable alternative to a Vampire Facelift.

A Vampire Facelift is a nonsurgical procedure. The results of this procedure are not permanent. A vampire facelift is a temporary solution. Although it’s a cosmetic surgery, it does not affect the body’s natural functions. A normal, healthy blood flow will help the body heal. A Vampire Facelift is a popular procedure for improving your appearance. Woodlands Wellness can help you achieve an even toned, youthful complexion.

Hormone Pellet Therapy: Benefits And Risks

At a certain age, the number of sex hormones starts to decline. This problem comes with its various effects on the human mind and body.

Regardless of gender, both males and females undergo this phenomenon.

However, this condition can also start in younger people due to some disease or external factors.

For dealing with this problem, hormone therapy is practiced which can be performed by various methods but hormone pellet therapy is the most reliable one.

Actually, the method of therapy has always been evolving. This evolution has provided us with the most effective method known as “hormone pellet therapy

The Procedure

  • Before the therapy, blood analysis is done for determining the quantity of hormones, one needs to overcome the deficiency.
  • If the analysis is not done properly it may lead to dangerous health problems due to excessive hormones in the blood.
  • The pellets are kept under the skin usually in the buttock
  • They keep releasing the hormones slowly for about 5–6 months. Usually, these hormones are biologically created from plants and are identical to our body’s hormones.
  • The patient needs to get examined by the doctor after some time to check if the pellets are delivering the right quantity. If the quantity has fallen off, a new pellet can be inserted.

Comparison of different kinds of methods used for hormone therapy

Benefits

  • Hormone pellet therapy is the most natural way. It is carefully regulated to avoid any problems.
  • It is a much consistent and long-lasting Moreover, it is a completely painless procedure.
  • You don’t have to remember any medicines or pills to take every day, instead, the pellet keeps delivering the hormones in the right amount without getting felt.
  • It is a very quick method and also requires very low maintenance. After the initial consultation, the patient can visit the doctor after every 3–4 months, saving the time of both doctor and the patient.
  • It also prevents the children in your house from consuming the hormones as nobody can access them under your skin. If taken in large quantities, can lead to health problems like HBP, heart disease, stroke, etc.

Risks

The hormone pellet therapy is actually a much effective way of therapy. The hormones have a significant effect on the patient’s health.

So, if any carelessness occurs, a large amount of hormones can enter and disrupt the balance causing medical issues like,

  • Acne
  • Hair fall
  • mood swings
  • Vaginal bleeding
  • Vision problems

Every medicinal drug has its side effects which are needed to be listed. But many of these hormones are not required to submit their side effects which does not provide a clear picture of the treatment for patients.

Moreover, a number of drug manufacturing companies are not focusing on the quality of these hormones, and some man-made compounds are also heard to be a component of these hormones. This irregularity needs to be solved otherwise leading to many medical side effects on long-term use.

Reference: Bubolo Medical

Layers of skin to pass for hormone pellet therapy

How does Botox treatment work and what should you know before getting this treatment?

Botox is the ideal treatment for all those who wish to have clean and clear skin with no wrinkles, creases, and aging lines that make them look old. It is an excellent treatment and the doctors have been using it for years for the treatment of skin issues and several other medical issues. The successful results of this treatment have made it one of the most trusted treatments in this field. Everywhere, you can find some really good clinics working to get this treatment done on your skin. For example,

Botox Fort Lauderdale FL has many options in this field and you would be delighted with the results that they produce.

How does the Botox treatment work?

Now that you have got an introduction to the Botox treatment, you might want to know how it works so that you can get the satisfaction that it is something up to the mark. The Botox treatment works in such a way that the signals go from the nerves to the muscles. The muscles, when they contract, they make the wrinkles and creases appear but the injected Botox helps the muscle to soften and relax so that the wrinkles are gone and you have smooth skin.

At which points can we use Botox treatment?

The Botox treatment has been successfully being used for decades for the treatment of the following areas on the face.

  1. Forehead lines
  2. Lines around the eyes also known as crow’s feet
  3. Frown lines

These lines can be cured with the help of the Botox treatment but remember that you cannot remove the lines caused by sunlight or gravity.

How long is the Botox procedure and is it painful?

The process of Botox treatment is very simple and hardly takes a few minutes. No anesthesia is used. Just a small need is injected into the specific area of the muscles on the face that helps with the relaxation of the muscles. The injection causes slight discomfort when it is applied. Therefore, the Botox treatment is something that is done in very little time and is the least painful as well.

The complete effect of the treatment can be seen only after two weeks of the procedure. Around ten days before the treatment, the doctor would advise you to stop taking alcohol and aspirin. So discuss it with New You Medical before the treatment.

Liquid biopsy: A life-saving innovation

Cancer is one of today’s leading causes of death, with colorectal cancer being among the three most common. This type of cancer is located in the colon and has a 65% survival rate within five years of its appearance. Survival of colon cancer patients, and all cancers, depends greatly on early detection. However, colon cancer patients often do not experience symptoms until late in the disease, and many of the symptoms may go unnoticed as minor ailments.

Specialists usually recommend routine tests for this type of disease to patients at risk, such as people over 50 years of age, although age is not an impediment to suffer from it, most patients are people between 50 and 74 years of age. Genetic predisposition is one of the most influential factors, so people with direct relatives who have suffered from this type of cancer should be aware of the risk, as well as those who present inflammatory colon diseases.

The most common colon cancer screening test consists of performing a tumor biopsy, a highly invasive and painful procedure, since the tumor must first be removed or a sample of it must be taken. The disadvantage of this technique lies not only in the patient’s discomfort, but also in the fact that only partial information on the disease’s progress is obtained.

Colon cancer being one of the cancers with the highest recovery rates in its early stages of detection, with more than 90% of cases of successful recovery in patients with early detection, has driven the development of new technologies for its earlier detection, being the liquid biopsy colon cancer a revolutionary invention. Liquid biopsies consist in the analysis of body fluids such as blood or saliva, colorectal cancer can be detected even before presenting symptoms, since it is a disease that alters the body in several ways and this can be detected in body fluids.

Advancements in this procedure have been achieved by AWSensors, which stands for Advanced Wave Sensors, a Spanish company specialized in the development of high-precision sensor technology for various areas, including clinical applications.

AWSensors participated jointly with other partners in two European projects: the LIQBIOPSENS project and the CATCH-U-DNA project, which consisted on the development of increasingly advanced liquid biopsy techniques. This procedure not only provides comfort to the patient by being non-invasive, but gives results in an average of one hour, and is much cheaper to perform than a tumor biopsy. The efficiency of this type of test is greater than traditional tests, provides additional information than the tumor biopsy, and facilitates the patient’s experience, who is usually under a lot of stress due to all the physical and psychological implications of traditional tests.

The liquid biopsy works with quartz crystal microbalance (QCM) sensor technology developed by the Polytechnic University of Valencia. This type of sensor detects various signals from the liquid samples and transforms the readings into electrical signals that enable the results to be obtained. QCM sensors have already been used for a long time in a wide range of areas, but microsensor technology has made it possible to transfer their use to sophisticated clinical disease where faster and miniaturized detection systems is demanded.

The projects were carried out in its trial stage, being tested on patients with colon cancer under the supervision of the Andalusian health service, showing positive results that drove the development of this type of technology. AWSensors  participated in the initiative through the funding of the study, development and research centers of the project, promoting the diversification of applications for this type of technology. The future application of this method is projected to positively impact patients physically, psychologically and financially, three essential aspects to maintain good health and mainly to increase the percentage of colorectal cancer survivors through early detection.

Hormone Treatment for Low Testosterone Levels in Older Men

Andrography, also known as testosterone therapy, is a kind of hormone therapy where synthetic hormones, particularly testosterone, are replaced or supplemented exogenously. ART is usually prescribed to treat the effects of male sexual hypogonadism, a condition where the production of testosterone is reduced in men. In men, the production of testosterone is increased during puberty and natural production decreases after menopause. In addition, there is some evidence that the regulation of gonadotropins and estrogen may be affected by androgenic therapy.

Various studies have shown that testosterone therapy Miami is effective in treating several common problems related to male sexuality. It can help men with erectile dysfunction, decrease in libido, decreased sperm count and presence of other sex-related abnormalities. However, andropause patients must be informed about the risks associated with andropause treatments and their expected long-term effects. Men should also be informed about the risks associated with the use of TRT for hypogonadal men.

One of the most common conditions treated with testosterone therapy is low bone mineral density. Testosterone supplements are known to stimulate the production of sex hormones, specifically testosterone, in the body. But the precise effects of testosterone therapy on the bone mineral density of older men is not yet known. For older men, especially those with hypogonadal menarche (low testosterone levels), the effects of testosterone therapy on bone mineral density are not known.

Because testosterone is primarily a male hormone, it is believed that how it affects androgenic alopecia is different from how it affects women. The decreased androgenic activity caused by aging in older men is likely due to the increased conversion of the androgen hormone into estrogen.

The decreased estrogen levels may impair the production of androgen receptors on target cells. Testosterone is a type of androgen, so the decreased activity at the receptors may act like a switchboard to send the wrong messages. It has been postulated that testosterone may act as a chemical or enzymatic shock to the target cells. Therefore, how testosterone therapy improves androgenic alopecia is not clear.

In a small number of older men, particularly those with low testosterone levels, testosterone therapy can cause severe adverse effects. These include mood swings, aggression, insomnia, and even erectile dysfunction. More research is needed to determine how low testosterone levels and testosterone therapy interact together in the body to treat conditions such as depression, irritability, insomnia, and erectile dysfunction. It is important that such studies be done to establish whether testosterone levels play a role in these illnesses.

As is the case with many other medications, testosterone is an active and potentially toxic substance in the body. Long-term use of testosterone therapy for low testosterone levels in older men may lead to severe adverse effects and possible risks. Because of the risk involved, younger men should not undergo testosterone therapy unless they have medical necessity.

Young men should have their testosterone levels tested prior to having their testosterone levels treated to prevent them from experiencing adverse side effects. It is extremely important that men discuss their testosterone level needs with their physician before undergoing any medical treatments to lower low testosterone levels.

Bio-Identical Hormones Therapy – Are There Any Benefits?

Bio-identical hormones have been around for decades. They are generally made from plant sources and are a great alternative to synthetic hormones. Many people still think bio-identical hormones in Woodlands are just a fad; they haven’t grasped the growing popularity and acceptance. Bio-identical hormone Woodlands have many benefits, but how can you tell which brand to go with? Here are some things to look for.

-The manufacturer should be FDA approved.

There’s a bit of controversy about bio-identical hormones in Woodlands. The Food and Drug Administration does not regulate commercial cosmetic products; however, they do regulate over-the-counter products. If a company won’t let you know if their products are safe or effective, there’s little reason to buy from them.

-What are the side effects?

There have been few, if any, reported side effects linked to bio-identical hormones. Some patients notice minor headaches or muscle pain during the first few weeks of taking the product, but these are short-term and only for those who are new to taking bio-identical hormones. More serious side effects are unlikely, as these are not the bio-identical hormones in use today.

-What can I do to alleviate my symptoms?

Right away, you can try drinking more water and other liquids, as well as eating more fruits and vegetables. The main bio-identical hormones in use today are mostly plant based and contain no artificial sweeteners, fragrances, or preservatives. These are the easiest and most effective ways to relieve symptoms, as long as you aren’t allergic to the plant hormones.

-What are the benefits?

In general, bio-identical hormones carry fewer risks for women than synthetic hormones, even when used for extended periods. Women who choose to take these drugs will not experience a significant increase in the risk of osteoporosis, heart disease, or breast cancer, though some of the benefits cannot be ruled out. For men, the benefits seem to be limited to erectile dysfunction and vaginal dryness. Men taking these drugs to treat male impotency have noted an increase in sperm count and better sex performance, but the benefits remain unproven for other men.

Unfortunately, pharmaceutical companies continue to lobby against bio-identical hormones therapy, warning that it could be dangerous. They claim that the long-term use of synthetic hormones could lead to cancers, heart attacks, stroke, or autoimmune disorders. But studies have not found a connection between bio-identical hormones and any of these ailments.

Bioidentical Hormones – Providing Ease With Menopause Symptoms

Bioidentical hormones have been heralded by critics as a “miracle cure” for women experiencing menopause symptoms such as hot flashes and night sweats. Bioidentical hormones are those that naturally produce the same hormones that are produced by the body.

Hormones play an integral part in regulating multiple aspects of the female physiology, including fertility and metabolism. This natural chemical process occurs without the woman’s awareness and can be interrupted for a variety of reasons, some of which are unrelated to menopause. However, despite their purported benefits, bioidentical hormones present some unique challenges that must be addressed when using them for menopause relief.

In most cases, women take hormones such as progesterone, estradiol and testosterone to regulate the effects of peri-menopause and to maintain hormonal balance. In some cases, bioidentical estrogens have been shown to increase cancer rates. These concerns have prompted questions about how bioidentical hormones are regulated and whether or not they are safe for women who are at risk for developing certain cancers. Bioidentical hormone therapy may actually cause cancer in some women, especially those who have a family history of breast cancer, uterine cancer or other cancers.

Despite these concerns, bio identical hormones Dallas Tx provide a unique menopause relief strategy that has been found to improve symptoms. The process involves ingesting plant based compounds that mimic estrogen and progesterone, as well as testosterone. The idea is that these compounds will mimic the body’s natural hormones, so that the body will not respond as it would with synthetic hormones. Over time, the body will begin to adjust to the process and produce more of the hormones that are needed for menopause relief. This process is one that does not adversely impact normal menstruation and will go unnoticed by most women.

While there are quite a few natural remedies that have been found to be effective menopause relief treatments, many physicians are now recommending bioidentical hormone therapy as an additional treatment option. This is because the process works so well that many patients notice increased energy levels and improved sleep patterns within just a few short weeks of beginning this treatment plan. There is no need for any patient to change their entire life in order to relieve menopause symptoms, as bioidentical hormone therapy allows patients to maintain the same lifestyle that they were already accustomed to. This type of menopause relief is also considered to be safe for all women of childbearing age.

Bioidentical hormones have become so popular that many clinics and physicians have started to offer this as part of a menopause relief program. For women who may not want to deal with hormones or surgery, this option provides a safe, gentle alternative for achieving menopause relief without going through invasive procedures. Doctors in the Dallas area are well familiar with bioidentical hormones, as many have used them to help their patients control their menopause symptoms.

With all the research and time that has been spent in developing bioidentical hormones, doctors know that they provide safe, effective treatment options for both men and women who are suffering from menopause symptoms. For these reasons, many women are choosing to turn to clinics in the Dallas area for help with menopause relief. The results show that both women and men experience similar relief when bioidentical hormones are used.

Many women may choose to treat their menopause symptoms with hormones that help them deal with hot flashes. These hot flashes occur as a reaction to hormone imbalances caused by menopause. Bioidentical hormones help to regulate these fluctuations so that women can more effectively cope with their menopause symptoms. Women no longer need to suffer with extreme temperature changes, night sweats and moodiness as long as they take an oral bioidentical hormone supplement. This type of menopause relief is an option that many physicians recommend.

Maintain Active Well-Being by Consuming Right Concentration of Cbd

The majority of smokers switches over to vaping and safeguards their lungs from the problem. It is an effective technique for people to take cbd. Smoking can affect people very much and lets people to experience the bad situation in their life. Vaping is so popular among smokers to start the consumption of cbd. You can carefully consume the full spectrum cbd oil uk and enjoy vaping with no discomfort.  It is a safe alternative for people to explore the potential benefits. It is perfect for people to minimize stress and anxiety. The users can gain added advantage when it comes to using the vape juice.

Discover good sensation:

It is the ideal solution for people to experience good vaping. It is a great solution for cbd users to feel relaxation and calmness. The users become more alert and make sure focus and strength. It is wonderful for people to keep up a sharp mind and think in the right way. The users can get rid of different symptoms like anxiety, stress, and depression. With the support of full spectrum cbd oil uk, you can gain quick relief. The users can feel the effects of vaping for up to two to three hours. You can buy the best flavor of juice and consume it throughout the day.

  • The users go for vaping because of the instantaneous effect on the body.
  • It is the best solution for cbd users to enjoy immediate relief from the issue.
  • You can solve health risk with potential medication.
  • This method of consumption is ideal for people to make sure quick and fast absorption of cbd.
  • You can use a vape device and fill the right amount of juice.
  • You can administer an ideal dose of the solution to enjoy good effects.

The users can keep up the vape device very handy and consume cannabis at any time. You can buy a cartridge or pen of any form. You can inhale the solution easily with the use of a vape tool.

Enjoy the healthy alternative:

You can understand the different aspect of the solution and decide to get great potency and concentration of juice. You can carry the device perfectly and feel positive effects on the body in a quick manner. It is advisable for people to carefully measure dose once decide to consume vape juice. It is ideal for people to customize their vaping experience. The users try to check the availability of vape juice first in the shop.

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